J. Am. Chem. Soc., 130 (12), 3710 -3711, 2008,Intracellular Spatial Control of Fluorescent Magnetic Nanoparticles.
[i]J. Am. Chem. Soc.,[/i] [b]130[/b] (12), 3710 -3711, 2008. 10.1021/ja7103125 S0002-7863(71)00312-3[b]Web Release Date:[/b] March 4, 2008 [size=-1][b]Copyright © 2008 American Chemical Society[/b][/size] [size=+2][b]Intracellular Spatial Control of Fluorescent Magnetic Nanoparticles [/b][/size]
[b]Jinhao Gao,[img]http://pubs.acs.org/images/entities/dagger.gif[/img][/b] [b]Wei Zhang,[img]http://pubs.acs.org/images/entities/Dagger.gif[/img][/b] [b]Pingbo Huang,[img]http://pubs.acs.org/images/entities/Dagger.gif[/img][/b] [b]Bei Zhang,[img]http://pubs.acs.org/images/entities/sect.gif[/img][/b] [b]Xixiang Zhang,[img]http://pubs.acs.org/images/entities/sect.gif[/img] and[/b] [b]Bing Xu*[img]http://pubs.acs.org/images/entities/dagger.gif[/img][/b]
[i]Departments of Chemistry, Biology, and Physics, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China [/i]
chbingxu@ust.hk [i]Received November 14, 2007 [/i]
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[b]Abstract:[/b]
We report a facile intracellular manipulation of fluorescent magnetic Fe3O4-CdSe nanoparticles using magnetic force. The growth of CdSe quantum dots on Fe3O4 nanoparticles produces Fe3O4-CdSe nanoparticles with two distinct properties, fluorescence and superparamagnetism. After nonspecific surface modification using glutathione (GSH), the hydrophilic Fe3O4-CdSe@GSH nanoparticles can be easily uptaken by an HEK293T cell line. Confocal images indicate that the uptaken nanoparticles can be manipulated using a small magnet. The successful intracellular manipulation of magnetic nanoparticles may offer a new strategy for studying polarized cells.
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