J. Am. Chem. Soc., ASAP Article - Total Synthesis of Lobatoside E, A Potent Antitumor Cyclic Triterpene Saponin
Chunsheng Zhu, Pingping Tang, and Biao Yu*State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
[email]byu@mail.sioc.ac.cn[/email]
Received March 5, 2008
Abstract:
Lobatoside E, a novel and complex cyclic triterpene saponin showing potent antitumor activities, has been synthesized for the first time, employing a highly modular approach. The synthesis, starting with oleanolic acid, D-glucose, D-galactose, L-arabinose, and L-rhamnose, requires a total of 73 steps, with the longest linear sequence of 31 steps and in 1.2% overall yield.
[img]http://pubs.acs.org/isubscribe/journals/jacsat/asap/figures/ja-2008-01669r_0003.gif[/img] 俞飙老师终于把这个big beast做出来了。
有一篇大陆学者的jacs的全合成。
翟宏斌，姚祝军，秦勇，俞飙......
希望这个list越来越长。
更希望早日在这个list再次看到马老师的名字。
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