J. Am. Chem. Soc., ASAP Article - Asymmetric Organocatalytic Three-Component 1,3-Dipolar Cycloaddition: Control of Stereochemistry via a Chiral Brønsted Acid Activated Dipole
Xiao-Hua Chen,†‡ Wen-Quan Zhang,† and Liu-Zhu Gong*†‡Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China, and Graduate School of Chinese Academy of Sciences, Beijing, China
[email]gonglz@ustc.edu.cn[/email]
Received February 11, 2008
Abstract:
A Brønsted acid catalyzed three-component asymmetric 1,3-dipolar addition reaction between aldehydes, amino esters, and dipolarophiles by a new bisphosphoric acid, derived from the linked BINOL, furnished multiply substituted pyrrolidines in high yield with excellent enantioselectivities under mild conditions.
[img]http://pubs.acs.org/isubscribe/journals/jacsat/asap/figures/ja-2008-01034e_0007.gif[/img]
[url]http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/asap/abs/ja801034e.html[/url] 龚留柱真会赶时髦，
以前做脯氨酸，现在做Bronsted酸。
势头很猛。
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