J. Am. Chem. Soc., ASAP Article - Tandem Michael Addition/Ylide Epoxidation for the Synthesis of Highly Functionalized Cyclohexadiene Epoxide Derivatives
Qing-Gang Wang,† Xian-Ming Deng,† Ben-Hu Zhu,‡ Long-Wu Ye,† Xiu-Li Sun,† Chuan-Ying Li,† Chun-Yin Zhu,† Qi Shen,‡ and Yong Tang*†State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 354 FengLin Lu, Shanghai 200032, China, and School of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215123, China
[email]tangy@mail.sioc.ac.cn[/email]
Received January 30, 2008
Abstract:
A highly efficient diastereoselective synthesis of cyclohexadiene epoxide derivatives with a multi-stereocenter has been developed via a tandem ylide Michael addition/epoxidation. By employing a chiral sulfonium ylide, up to 96% ee can be achieved in good yields.
[img]http://pubs.acs.org/isubscribe/journals/jacsat/asap/figures/ja-2008-00747m_0007.gif[/img]
[url]http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/asap/abs/ja800747m.html[/url] 唐勇老师的yelide越做越好了。
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