Enantioselective Total Synthesis of Phomallenic Acid C
Ya-Jun Jian, Chao-Jun Tang, and Yikang Wu*State Key Laboratory of Bioorganic And Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China
[email]yikangwu@.sioc.ac.cn[/email]
Received March 17, 2007
Abstract:
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The newly isolated bacterial FAS II inhibitor phomallenic acid C (3) was synthesized for the first time as a 16:1 mixture of the (R)- and (S)-isomer with the diyne-allene motif constructed using a coupling under Negishi conditions. By comparison with the synthetic sample, the natural phomallenic acid C was estimated to be a 3.8:1 mixture of (R)-/(S)-isomers. This synthesis describes a new synthetic entry to optically active allene diynes.
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[color=red][fbox=Random Bonus]Congratulations to yajunjian, who obtained 3 token(s) from the system by posting this thread.[/fbox][/color] 欢迎上海有机所的朋友 欢迎欢迎。
这个分子终于做完了，
记得TCJ当年做的可痛苦了，
差点毕不了业。
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