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andy 发表于 2008-9-4 23:26

[Journal of Applied Polymer Science] A biodegradable diblcok copolymer poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate): Docetaxel and RGD conjugation

Authors:Zhigang Xie , Xiuli Hu , Xuesi Chen, Tiancheng Lu, Shi Liu, Xiabin Jing

Web Release Date: 3 Sep 2008

DOI: 10.1002/app.28900

Abstract:A diblcok copolymer monomethoxy poly (ethyleneglycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate) (MPEG-b-P(LA-co-MCC)) was obtained by copolymerization of L-lactide (LA) and 2-methyl-2-benzoxycarbonyl-propylene carbonate (MBC) and subsequent catalytic hydrogenation. The pendant carboxyl groups of the copolymer MPEG-b-P(LA-co-MCC) were conjugated with antitumor drug docetaxel and tripeptide arginine-glycine-aspartic acid (RGD), respectively. 1H-NMR spectra confirmed the structure of the copolymer MPEG-b-P(LA-co-MCC/docetaxel) and MPEG-b-P(LA-co-MCC/RGD). In vitro antitumor assay indicates that the MPEG-b-P(LA-co-MCC/docetaxel) conjugate shows high cytotoxic activity against HeLa cancer cells. Cell adhesion and spreading experiment shows that copolymer MPEG-b-P(LA-co-MCC/RGD) is of benefit to cell adherence and is a promising biodegradable material for cell and tissue engineering.

Link:[url]http://www3.interscience.wiley.com/journal/121392834/abstract[/url]

Remarks: very common paper

[[i] 本帖最后由 andy 于 2008-9-4 23:27 编辑 [/i]]

asymmsyn 发表于 2008-9-5 06:21

Congratulations!!

hnlj 发表于 2008-9-5 07:26

congratulation

congratulation:)

popeye.cn 发表于 2008-9-5 07:51

恭喜恭喜

Metalcarbene 发表于 2008-9-6 04:42

恭喜下:lol

churen 发表于 2008-9-6 06:43

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cons!

sekowa 发表于 2008-9-6 08:23

路过
看看
！！

andy 发表于 2008-10-25 23:37

看看

churen 发表于 2008-10-27 05:47

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