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Title:
Fragment-based Approaches in Drug Discovery |
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Division: Medicinal / John Wiely & Son / 英文版 |
Author/Editor: Wolfgang Jahnke, Daniel A. Erlanson Star:  |
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ISBN: 3527312919 |
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Introduce Date: 2006年09月14日18:41 , Release Date: 2006年09月14日19:58 |
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Introducer: crisoo , Rate: 7/321 |
| Format: pdf(editorial) Download |
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| Appraiser: yyhsz04 | Grade: +1 | Reason: ( 终于找到了 ) | | | Appraiser: cola2006 | Grade: +5 | Reason: ( 这本书很棒 ) | | | Appraiser: chemzhang | Grade: +5 | Reason: ( 刚刚加错了。 ) | | | Appraiser: chemzhang | Grade: +1 | Reason: ( 好书，真想看。 ) | | | Appraiser: Reuben | Grade: +5 | Reason: ( Thank you fro sharing! ) | |
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| Description: |
Fragment-based Approaches in Drug Discovery
Wolfgang Jahnke (Editor), Daniel A. Erlanson (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor)
ISBN: 3-527-31291-9
Hardcover
392 pages October 2006 Wiley List Price: US $190.00
This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.
Front Matter (p I-XXII)
Part 1: Concept and Theory
Chapter 1: The Concept of Fragment-based Drug Discovery (p 1-10)
Chapter 2: Multivalency in Ligand Design (p 11-53)
Chapter 3: Entropic Consequences of Linking Ligands (p 55-66)
Chapter 4: Location of Binding Sites on Proteins by the Multiple Solvent Crystal Structure Method (p 67-88)
Part 2: Fragment Library Design and Computional Approaches
Chapter 5: Cheminformatics Approaches to Fragment-based Lead Discovery (p 89-111)
Chapter 6: Structural Fragments in Marketed Oral Drugs (p 113-124)
Michal Vieth, Miles Siegel
Chapter 7: Fragment Docking to Proteins with the Multi-copy Simultaneous Search Methodology (p 125-146)
Part 3: Experimental Techniques and Applications
Chapter 8: NMR-guided Fragment Assembly (p 147-180)
Chapter 9: SAR by NMR: An Analysis of Potency Gains Realized Through Fragment-linking and Fragment-elaboration Strategies for Lead Generation (p 181-192)
Chapter 10: Pyramid: An Integrated Platform for Fragment-based Drug Discovery (p 193-214)
Chapter 11: Fragment-based Lead Discovery and Optimization Using X-Ray Crystallography, Computational Chemistry, and High-throughput Organic Synthesis (p 215-248)
Chapter 12: Synergistic Use of Protein Crystallography and Solution-phase NMR Spectroscopy in Structure-based Drug Design: Strategies and Tactics (p 249-266)
Chapter 13: Ligand SAR Using Electrospray Ionization Mass Spectrometry (p 267-283)
Chapter 14: Tethering (p 285-310)
Daniel A. Erlanson, Marcus D. Ballinger, James A. Wells
Summary | Full Text: PDF (Size: 485K)
Part 4: Emerging Technologies in Chemistry
Chapter 15: Click Chemistry for Drug Discovery (p 311-339)
Chapter 16: Dynamic Combinatorial Diversity in Drug Discovery (p 341-364)
Index (p 365-369)
http://www3.interscience.wiley.com/cgi-bin/bookhome/112729017
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