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Title:
Small Molecule DNA and RNA Binders |
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Division: Biotechnology / John Wiely & Son / 英文版 |
Author/Editor: Demeunynck, Martin , Bailly, Christian , Wilson, W.David Star:  |
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ISBN: 3527305955 |
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Introduce Date: 2006年06月29日12:14 , Release Date: 2006年06月29日12:38 |
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Introducer: Reuben , Rate: 16/371 |
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| Description: |
Published Price: £250.00
ISBN: 3527305955
Published By: VCH Verlagsgesellschaft,Germany
Publication Date: 14 March 2003
Format: Cloth / Hardback, 754pages, 24.5cm height
Category: organic chemistry
Category: chemistry
Languages: English
Brief Description:
In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present approaches to drug design.
Synopsis:
The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.
Table Of Contents
Front Matter (p i-xxii)
Part 1: Volume 1
Chapter 1:
Forty Years On (p 1-17)
Prof. Michael J. Waring, L. P. G. Wakelin
Chapter 2:
Targeting HIV RNA with Small Molecules (p 18-40)
Nathan W. Luedtke, Prof. Dr. Yitzhak Tor
Chapter 3:
RNA Targeting by Bleomycin (p 41-57)
Prof. Dr. Sidney M. Hecht
Chapter 4:
Inhibitors of the Tat-TAR Interactions (p 58-87)
Chimmanamada U. Dinesh, Tariq M. Rana
Chapter 5:
DNA and RNA Recognition and Modification by Gly-Gly-His-Derived Metallopeptides (p 88-125)
Dr. Eric C. Long, Craig A. Claussen
Chapter 6:
Salen-Metal Complexes (p 126-145)
Dr. S. E. Rokita, C. J. Burrows
Chapter 7:
Charge Transport in DNA (p 146-177)
Tashica T. Williams, Jacqueline K. Barton
Chapter 8:
DNA Interactions of Novel Platinum Anticancer Drugs (p 178-223)
Dr. Viktor Brabec, Jana Kasparkova
Chapter 9:
Electrochemical Detection of DNA with Small Molecules (p 224-246)
Shigeori Takenaka
Chapter 10:
Design and Studies of Abasic Site Targeting Drugs: New Strategies for Cancer Chemotherapy (p 247-277)
Dr. Jean-François Constant, Dr. Martine Demeunynck
Chapter 11:
Interactions of Macrocyclic Compounds with Nucleic Acids (p 278-314)
Marie-Paule Teulade-Fichou, Dr. Jean-Pierre Vigneron
Chapter 12:
Triplex- versus Quadruplex-Specific Ligands and Telomerase Inhibition (p 315-336)
Patrizia Alberti, Magali Hoarau, Lionel Guittat, Masashi Takasugi, Paola B. Arimondo, Laurent Lacroix, Martin Mills, Marie-Paule Teulade-Fichou, Dr. Jean-Pierre Vigneron, Jean-Marie Lehn, Patrick Mailliet, Dr. Jean-Louis Mergny
Part 2: Volume 2
Chapter 13:
Design and Analysis of G4 Recognition Compounds (p 337-359)
Shozeb Haider, Gary N. Parkinson, Martin A. Read, Prof. Dr. Stephen Neidle
Chapter 14:
Triple Helix-Specific Ligands (p 360-383)
Prof. Dr. Keith R. Fox, Richard A. J. Darby
Chapter 15:
Polyamide Dimer Stacking in the DNA Minor Groove and Recognition of T·G Mismatched Base Pairs in DNA (p 384-413)
Eilyn R. Lacy, Erik M. Madsen, Dr. Moses Lee, Prof. Dr. W. David Wilson
Chapter 16:
Dicationic DNA Minor Groove Binders as Antimicrobial Agents (p 414-460)
Richard R. Tidwell, Dr. David W. Boykin
Chapter 17:
Energetics of Anthracycline-DNA Interactions (p 461-481)
Dr. Jonathan B. Chaires
Chapter 18:
Acridine-4-Carboxamides and the Concept of Minimal DNA Intercalators (p 482-502)
William A. Denny
Chapter 19:
DNA Topoisomerase-Targeted Drugs (p 503-537)
Dr. M. Palumbo, B. Gatto, C. Sissi
Chapter 20:
Targeting DNA and Topoisomerase I with Indolocarbazole Antitumor Agents (p 538-575)
Dr. Christian Bailly
Chapter 21:
Defining the Molecular Interactions that are Important for the Poisoning of Human Topoisomerase I by Benzimidazoles and Terbenzimidazoles (p 576-608)
Dr. Daniel S. Pilch, Hsing-Yin Liu, Tsai-Kun Li, John E. Kerrigan, Edmond J. LaVoie, Christopher M. Barbieri
Chapter 22:
Binding and Reaction of Calicheamicin and Other Enediyne Antibiotics with DNA (p 609-642)
Joseph P. Cosgrove, Dr. Peter C. Dedon
Chapter 23:
Devising a Structural Basis for the Potent Cytotoxic Effects of Ecteinascidin 743 (p 643-675)
Federico Gago, Dr. Laurence H. Hurley
Chapter 24:
The Azinomycins. Discovery, Synthesis, and DNA-Binding Studies (p 676-696)
Maxwell Casely-Hayford, Dr. Mark Searcey
Chapter 25:
The Generation and DNA-Interaction of PBD and CBI Libraries (p 697-710)
Alison Hardy, Jane M. Berry, Natalie Brooks-Turner, Philip W. Howard, John. A. Hartley, Dr. David. E. Thurston
Index (p 711-732)
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