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Title:
Handbook of Carbohydrate Engineering |
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Division: Food Chem / CRC Press / 英文版 |
Author/Editor: Kevin J. Yarema (Editor) Star:  |
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ISBN: 1574444727 |
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Introduce Date: 2007年10月08日20:20 , Release Date: 2007年10月08日22:18 |
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Introducer: xwtsq , Rate: 3/186 |
| Format: pdf(editorial) |
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| Appraiser: loriy | Grade: +1 | Reason: ( 这本书还行 ) | |
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| Description: |
Book Details
Hardcover: 944 pages
Publisher: CRC (May 27, 2005)
Language: English
ISBN-10: 1574444727
ISBN-13: 978-1574444728
Product Dimensions: 9.4 x 6.4 x 2.2 inches
Shipping Weight: 3.1 pounds
Book Description
◎ Presents a broad overview of the principles, processes, and applications of carbohydrate engineering
◎ Incorporates results from biologists, chemists, and chemical engineers in research and development as well as applied areas
◎ Offers foundation-to-application format that is accessible to all levels of scientists and researchers
◎ Provides practical information on current and future research methodologies for characterization and synthesis
◎ Includes cutting edge topics such as antibody engineering, crop nutrient modification, and computer modeling and systems biology analysis of carbohydrates
The Handbook of Carbohydrate Engineering provides an overview of the basic science, theory, methods, and applications of this broad, interdisciplinary field. The text provides background information along with practical knowledge for current and future research methodologies used in the characterization and synthesis of various carbohydrates. This multidisciplinary perspective involves aspects of basic biology, synthetic chemistry, enzymology, complex instrumentation, and sophisticated modeling.
The book presents the fundamentals of carbohydrate engineering, addressing concepts in structure, biosynthesis, and biological functions for a variety of carbohydrates with a particular emphasis on mammalian glycoproteins and their N-linked oligosaccharides, glycolipids, sialic acid, as well as polysaccharides from both eukaryotes and bacteria. It describes glycosylation processes found in nature and surveys methods to manipulate these metabolic systems in living cells both for the improved production of carbohydrates and to give these molecules novel properties. Subsequent sections discuss the various methods of purification, synthesis, modification, and analysis used to create and manipulate carbohydrates in the laboratory; these approaches include chemical-enzymatic synthesis, small-molecule cell-based strategies, as well as complete chemical synthesis.
The Handbook of Carbohydrate Engineering also focuses on practical applications for carbohydrates. It emphasizes methods to characterize glycosylation pathways and expounds upon the role of carbohydrates in health and disease, a significant - and rapidly growing - area of research. World-renowned experts discuss biomedical applications, including the development of vaccines, therapeutics, glycomimetics, antibody engineering, drug delivery, tissue engineering and organ regeneration, and diagnostic agents. Several chapters also cover important applications in agriculture, industry, food technology, and environmental remediation.
Table of Contents :
1. Mammalian Glycosylation: An Overview of Carbohydrate Biosynthesis
2. Patterning of Lectins of Vero and MDCK Cells and Influenza Viruses: The Search for Additional Virus/Cell Interactions
3. O-Acetyl Sialic Acids in Parasitic Diseases
4. Congenital Disorders of Glycosylation
5. Role of Milk Carbohydrates in Preventing Bacterial Adhesion;Structural 5. Characterization of Glycosaminoglycans
6. Carrageenans: Structural and Conformational Studies
7. Computational Modeling in Glycosylation
8. Biosynthetic Pathways for Differential Expression of Functional Chondroitin Sulfate and Heparan Sulfate
9. Large-Scale Production of Oligosaccharides Using Engineered Bacteria
10. Fructan Biosynthesis in Genetically-Modified Plants;
11. Chinese Hamster Ovary (CHO) Glycosylation Mutants for Glycan Engineering
12. Biochemical Engineering of Sialic Acids
13 Glycosylation in Native and Engineered Insect Cells
14. N-Glycan Engineering in Yeasts and Fungi: Progress Toward Human-Like Glycosylation
15. Bacterial Capsules: A Route for Polysaccharide Engineering
16. Chemo-Biological Approach to Modification of the Bacterial Cell Wall
17. Engineering Bacterial Biopolymers for the Biosorption of Heavy Metals
18. Treatment of Wastewaters with the Biopolymer Chitosan
19. The Role of Glycosylation in Engineered Antibodies
20. Recent Developments in the Synthesis of Oligosaccharides by Hyperthermophilic Glycosidases
21. Modification of Plant Cell Wall Polysaccharides Using Enzymes from Aspergillus
22. Glucosidases from Filamentous Fungi: Properties, Structure, and Applications
23 Sialic Acids and Sialylmimetics: Useful Chemical Probes of Sialic Acid-Recognizing Proteins
24 Engineering Carbohydrate Scaffolds into the Side Chains of Amino Acids and Use in Combinatorial Synthesis
25 Effects of Short- and Long-Chain Fructans on Large Intestinal Physiology and Development of Pre-Neoplastic Lesions in Rats
26 Alginate as Drug a Delivery Carrier
27 Chitosan-Based Nonviral Vectors for Gene Delivery
28 Polysaccharides in Tissue Engineering Applications
Index
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