Structure-Based Drug Discovery - An Overview
DOI: 10.1039/9781847552549
Roderick E Hubbard (Editor)
ISBN (online): 978-1-84755-254-9
ISBN (print): 978-0-85404-351-4
Copyright: 2006
Table of Contents
Title Page
Front matter
DOI: 10.1039/9781847552549-FP001 (67Kb)
Preface
DOI: 10.1039/9781847552549-FP005 (28Kb)
Acknowledgements
DOI: 10.1039/9781847552549-FP009 (18Kb)
Contents
DOI: 10.1039/9781847552549-FP011 (43Kb)
3D Structure and the Drug Discovery Process
DOI: 10.1039/9781847552549-00001 (151Kb) 1
Structure Determination - Crystallography for Structure-Based Drug Discovery 32
Molecular Modelling 54
Applications of NMR in Structure-Based Drug Discovery 97
Fragment Screening: An Introduction 142
Iterative Structure-Based Screening of Virtual Chemical Libraries and Factor Xa: Finding the Orally Available Antithrombotic Candidate LY517717 173
Anti-Influenza Drugs from Neuraminidase Inhibitors 193
Isoform Specificity: The Design of Estrogen Receptor-0‰8 Selective Compounds 219
Subject Index 257