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Title:
Peptides: Chemistry and Biology |
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Division: Biotechnology / John Wiely & Son / 英文版 |
Author/Editor: Norbert Sewald and Hans-Dieter Jakubke Star:  |
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ISBN: 3527304053 |
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Introduce Date: 2006年07月20日04:21 , Release Date: 2006年07月20日11:10 |
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Introducer: westwolf , Rate: 19/397 |
| Format: pdf(scanned) Download |
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| Appraiser: jssy22 | Grade: +1 | Reason: ( 这本书很棒 ) | |
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| Description: |
Peptides: Chemistry and Biology
Norbert Sewald, Hans-Dieter Jakubke
ISBN: 3-527-30405-3
Hardcover
597 pages
September 2002
Wiley List Price: US $135.00
A compact introduction to modern peptide research and a comprehensive reference in one volume. This unique volume covers all the relevant chemical and biological aspects of this wide-ranging field in a concise and easily comprehensible manner. These include the physiological importance, structure, analysis, synthesis, peptide libraries and peptide design. Specialists and experts in particular will profit from the first-class encyclopedic appendix with data on more than 500 physiologically active peptides and proteins.
From the contents
INTRODUCTION AND BACKGROUND
FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES Definitions and main conformational features of the peptide bond
Building blocks, classification and nomenclature
Analysis of the covalent structure of peptides and proteins
Three-dimensional structure
Methods of structural analysis
BIOLOGICALLY ACTIVE PEPTIDES
Occurrence and biological roles
Biosynthesis
Selected bioactive peptide families
PEPTIDE SYNTHESIS
Principles and objectives
Protection of functional groups
Peptide bond formation
Racemization during synthesis
Solid phase peptide synthesis (SPPS)
Biochemical synthesis
SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS
Strategy and tactics
Synthesis in solution
Optimized strategies on polymeric support
Ligation of unprotected peptide segments
SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES
Cyclopeptides
Cystine peptides
Glycopeptides
Phosphopeptides
Lipopeptides
Sulfated peptides
PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, PEPTIDOMIMETICS
Peptide design
Modified peptides
Peptidomimetics
Pseudobiopolymers
Macropeptides and de novo design of peptides and proteins
COMBINATORIAL SYNTHESIS
Parallel synthesis
Synthesis of mixtures
APPLICATION OF PEPTIDES AND PROTEINS
Protein pharmaceuticals
Large scale peptide synthesis
Peptide pharmaceuticals
Peptide drugs and new drug assays
The book by Sewald and Jakubke is most timely and will be extremely useful for students and researchers in peptide science. The authors address the broad fundamentals of peptide synthesis and structure. They also identify important families of biologically active peptides.
Lastly, they bring their impressive treatment up to the most current of peptide activities including pseudopeptides, peptidomimetics, combinatorial syntheses and applications of peptides as pharmaceuticals and in biotechnology. The book is an impressive addition to the field and will help researchers identify peptide derivatives as key target molecules for pharmaceuticals and novel structures in biotechnology. - Murray Goodman, Univ. of California, San Diego
"...absolutely excellent book, handsomely produced and underpriced..."(European Peptide Society Newsletter, 1 January 2003)
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