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Title:
Drug Metabolism - Chemical and Enzymatic Aspects (Textbook Edition) |
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Division: General Biochemistry / CRC Press / 英文版 |
Author/Editor: Jack P. Uetrecht, William Trager Star:  |
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ISBN: 1420061038 |
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Introduce Date: 2007年12月27日04:08 , Release Date: 2008年01月31日17:10 |
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Introducer: chaoyuan , Rate: 1/148 |
| Format: pdf(editorial) Download |
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| Description: |
Drug Metabolism: Chemical and Enzymatic Aspects: Textbook Edition
Jack P. Uetrecht, M.D. PhD University of Toronto, Leslie Dean Faculty of Pharmacy, Toro
William Trager University of Washington, Seattle, USA (Ret.)
List Price: $69.95
Web Price: $62.96
You Save: $6.99
Cat. #: H1038
ISBN: 9781420061031
ISBN 10: 1420061038
Publication Date: 6/21/2007
Number of Pages: 200
Availability: In Stock
# An essential reference for the study of drug metabolism, this textprovides a review of kinetic aspects of drug metabolism
# presents detailed information describing oxidative enzymes and the oxidative pathways of drug metabolism-emphasizing mechanistic aspects of cytochrome P450-mediated reactions
# discusses what makes a metabolite chemically reactive, examples of reactive metabolites, and the clinical implications of reactive metabolites for adverse drug reactions, other types of toxicity, and drug development
# opens with a review for non-chemist then explains the importance of drug metabolism, how to read the structure of a drug, and write a chemical mechanism
# is methodized with text analysis for lecturing in the classroom, followed by practical problems for the cultivation of students within the laboratory setting
In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structures and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This comprehensive textbook will aid in guiding students through the recognition of the chemical underpinnings of drug metabolism. While there are numerous resources available for understanding drug structure, and other texts relating to drug metabolism from a biological standpoint, there is no other resource currently available that links both the chemical and biological terminology together in a clear and concise language, written, to be accessible for use in the classroom, as an education tool for teaching drug development. Drug Metabolism: Chemical and Enzymatic Aspects explains, to teachers and students alike, how a drug is metabolized, the potential effects of the metabolites, extensive material to help understand drug metabolism within a biological context, and practical problems and answers.
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