This book provides a detailed description of the general principles and strategies for solving chemical synthesis problems of complex organic molecules. It is the only book to deal systematically with the fundamental principles of synthetic problem solving.
GENERAL APPROACHES TO THE ANALYSIS OF COMPLEX SYNTHETIC PROBLEMS.
The Basis for Retrosynthetic Analysis.
Transform-Based Strategies.
Structure-Based and Topological Strategies.
Stereochemical Strategies.
Functional Group-Based and Other Strategies.
Concurrent Use of Several Strategies.
SPECIFIC PATHWAYS FOR THE SYNTHESIS OF COMPLEX MOLECULES.
Macrocyclic Structures.
Heterocyclic Structures.
Sesquiterpenoids.
Polycyclic Isoprenoids.
Prostanoids.
Leukotrienes and Other Bioactive Polyenes.
GUIDE TO THE ORIGINAL LITERATURE OF MULTISTEP SYNTHESIS.