From: jobs at ccl.net (do not send your application there!!!)
To: jobs at ccl.net
Date: Mon Feb 4 07:07:45 2008
Subject: 08.02.04 Fellowships for Ph.D. students, Konstanz Research School - Chemical Biology (KoRS-CB). University of Konstanz
The University of Konstanz is one of the nine Excellence Universities of the
Federal Republic of Germany.
Konstanz Research School - Chemical Biology (KoRS-CB): Research and Graduate
Training at the Interface of Chemistry and Biology
The newly founded "Konstanz Research School - Chemical Biology" (KoRS-CB) is
an interdisciplinary initiative of the Departments of Biology, Chemistry,
and Computer and Information Science at the University of Konstanz and is
supported by the German Excellence Initiative.
The main objective of KoRS-CB is to guide talented graduate students to
scientific excellence in an area that is highly relevant for both basic and
applied research. The research program of KoRS-CB comprises the research
areas Synthetic Chemistry, Cellular Biochemistry, Biophysics, Biomedicine,
and Computational Biology.
KoRS-CB will commence its training program in April 2008. Thus, KoRS-CB
invites applications for
FELLOWSHIPS FOR PH.D. STUDENTS
from highly motivated and enthusiastic students with a keen interest in
interdisciplinary research and an excellent degree (Master or Diploma) in
Biology, Chemistry or related areas.
The University of Konstanz is a true campus university located on spacious
grounds within one of the most beautiful areas of Germany overlooking Lake
Constance and close to the Alps. The University of Konstanz is one of nine
German universities that have been awarded the status of a "University of
Excellence" by the German Excellence Initiative and provides state-of-the-
art research facilities for interdisciplinary and cutting-edge research.
PROJECT P1: Analysis of Molecular Dynamics Simulation of Complex
Biochemical Systems
Molecular dynamics simulations are increasingly used to analyze, explain,
and predict very complex processes in biological systems on an atomic
level (like protein folding and drug-receptor interactions). In these
simulations, the movement of all atoms is calculated with a time step of
1 to 2 fs over a total simulation time of ns to ms. In this way, an
ensemble of 106 to 109 conformations of the system composed out of up to
100000 atoms and more is generated, which describe, on the one hand, the
thermal fluctuations of the atoms around stable conformations of the
biomacromolecules, and, on the other hand, the more interesting global
movements of larger domains needed for the biological function. But due
to the huge amount of data, it is very difficult to extract these latter,
essential movements. Therefore, data-mining techniques, like clustering,
will be adapted to automatically group and make sense of the information
in a simulation trajectory. It is important that the criteria for such a
clustering will be determined with respect to the data at hand. In the
beginning of the investigation, it is not clear, which part of a specific
molecular systems plays the dominate role leading to the conformational
change. Even large movements of protein domains can be initialized by
rotations of single amino-acid side chains. A hierarchical approach using
different abstraction levels is anticipated for finding the global changes
but then also to look into the local changes on the paths leading to the
global ones. After this analysis, the different levels will be visualized
for better interpretability by the investigator. Here, new interactive
techniques are needed to highlight the extracted dynamical processes.
For details on the application procedure and further information on the
research and training program of KoRS-CB, the participating Departments
and the University of Konstanz, please visit the KoRS-CB homepage at
www.chembiol.uni-konstanz.de or contact Ms Ilonka Muench, -
e-mail: ChemBiol^uni-konstanz.de Konstanz Research School Chemical
Biology, University of Konstanz, 78457 Konstanz, Germany.
Please send your application to the office of the Konstanz Research
School Chemical Biology in single file via Email to:
chembiol^uni-konstanz.de until 17th February, 2008.
http://ccl.net/cca/jobs/joblist/mess0011871.shtml
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