| Room: | CH 12.1.82 |  |
| Phone: | +49-941-943-4065 | |
| Fax: | +49-941-943- 4064 | |
| E-mail: | otto.wolfbeis@chemie.uni-regensburg.de | |
| Address: | University of Regensburg Institute of Analytical Chemistry, Chemo- and Biosensors 93040 Regensburg, Germany |
Status
| Name | Otto S. Wolfbeis |
| Born | 18. Juli 1947, Graz, Austria |
| Affiliation | University of Regensburg Institute of Analytical Chemistry, Chemo- and Biosensors D-93040 Regensburg, Germany |
| Phone Fax Web | (+49)(941)943-4065 (+49)(941)943-4064 otto.wolfbeis@chemie.uni-r.de www.wolfbeis.de |
| Present Status | Full Professor of Analytical and Interface Chemistry |
| Education | PhD in chemistry (1972; University of Graz) |
Professional Experience
1972 - 1974 Post-doctoral fellow at the Max-Plack Institute for Radiation Chemistry, Muelheim (Germany) with Prof. Koerner von Gustorf
1976 - 1977 Post-doc at the Technical University Berlin with Prof. E. Lippert
1977 - 1987 Assistant Professor at Karl-Franzens University, Graz, Austria
1987 - 1995 Associate Professor at KFU Graz
1990 - 1992 Founding Director of the Institute of Optical Sensors, Joanneum Research, Graz
1995 - present Full Professor of Analytical and Interface Chemistry at the University of Regensburg (UoR)
Teaching
General Analytical Chemistry, Chemical Sensor and Biosensor Technology, Fluorescent Probes, Conjugation and Immobilization, Interface Chemistry
Administration
1995 - present Director of Institute
1998 - 2000,
2007 - present Member of the Senate of the UoR
1998 - present Head of the UoR Laboratory for Environmental Radioactivity (URA)
2000 - 2002 Dean of the Faculty of Chemistry and Pharmacy
2001 - 2005 Head of the Center for Postgraduate Education of the UoR
2002 - 2004 Vice Rector of the UoR
2004 - present Regensburg Representative of the Bavarian Elite Academy
Research
General Chemical and biochemical sensing schemes, bioanalytical (laser-induced) fluorescence spectrometry; design of fluorescent probes and labels including metal-ligand complexes; fluorescent nanoparticles for labeling and encoding; fluorescence imaging; interface (bio)chemistry; molecular imprints in nm dimensions; new polymers and sensor materials; impedimetric biosensing; surface plasmon resonance biosensing.
By application Sensors for use in clinical settings and in biotechnology, in disposable or microplate format; immunoassays and hybridization assays; high-throughput screening, sensors for dermatology
Patents named (co)inventor of 47 patents (Eur; US, Jpn)
Papers > 460
Book Chapters 13
Books edited (a) Fiber Optic Chemical Sensors and Biosensors, CRC Press, Boca Raton, 1991, vols. 1 & 2;
(b) Fluorescence Spectroscopy: New Methods and Applications, Springer, 1993;
(c) Near-Infrared Dyes for High Technology Applications, S. Daehne, U. Resch-Genger, O. S. Wolfbeis, Kluwer, 1998;
(d) Optical Sensors for Industrial, Environmental and Clinical Applications, R. Narayanaswamy, O. S. Wolfbeis (eds.), Springer, 2004.
Other Activities
Editor-in-Chief - of Microchimica Acta (2002 - present);
- of the Springer Series on Methods and Applications of Fluorescence
- of the Springer Series on Chemical Sensors and Biosensors (2000 - 2006)
Curatorship
Angewandte Chemie (2006 - present)
Journal Boards
Analytica Chimica Acta (1988 - 2004), J. Fluorescence (1992 - present), Sensors & Actuators (1991 - present), Anal. Bioanal. Chem. (a.k.a. Fresenius' J. Anal. Chem.) (1989 - 2007)
Chairman
– of the Eur. Section of the Society of Fluorescence
– of the Permanent Steering Committee of the Conference Series on Optical Chemical Sensors and Biosensors (biannual); this conference series founded by O. S. Wolfbeis in 1992.
– of the Permanent Steering Committee of the Conference Series on Methods and Applications of Fluorescence (biannual); this conference series founded by O. S. Wolfbeis in 1989.
– of the Selection Committee for the Roche Prize for Sensor Technology (2000 to 2006)
– of ASCOS (Advanced Study Course for Optical Sensors; a biannual Eur. Study course to train students in optical sensor technology (1998 – 2004); this conference series was founded by R. Kellner† and O. S. Wolfbeis in 1992.
Companies
Founder, and Chairman of the Board, of Chromeon GmbH (2001 – 2005); now Active Motif Chromeon GmbH.
Honors
1982 Sandoz Prize for Chemistry
1987 Feigl Prize for Microanalysis
1989 Merck Prize for Achievements in Sensor Technology
1996 Friedrich-Emich Medal for Molecular Spectroscopy (Austrian Chem. Soc.)
and others
homepage: http://www-analytik.chemie.uni-regensburg.de/Wolfbeis/
[ 本帖最后由 sally208 于 2008-6-24 21:17 编辑 ]
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Analytical Fluorescence Spectroscopy
measurement of decay time
resonance energy transfer (FRET & PRET)
photo-induced electron transfer (ion sensing)
dual-luminophore referencing (intensity-to-phase conversion)
single molecule detection
fluorescence microscopy
upconversion
timeresolved fluorescence
Fluorescence Assays for
ions
gases (also dissolved)
hydrogen peroxide
antibodies
oligonucleotides
pesticides and enzyme inhibitors
enzyme substrates incl. glucose and urea
albumin
Fluorescence Probes
for oxygen, pH, alkali ions, halides, H2O2
for saccharide recognition
probes based on photo-induced electron transfer
µs decay time probes
polarity-sensitive probes
near-infrared probes
DNA intercalators
C70 as a probe for O2
Fluorescence Labels
for proteins and DNAs (covalent labeling)
diode laser-compatible labels
with µs decay times (ruthenium lables)
nanoparticles
labels for electrophoresis
Optical Sensors (mainly fluorescent)
for oxygen (gaseous and dissolved)
for pH and ions (Na+, K+, Cl-)
for gases incl. CO2, ammonia, SO2, HCl
for glucose
fiber optic sensors (20 µm - 1 mm)
dual sensors (O2/pH; O2/temp.; CO2/O2 etc.)
pressure-sensitive paints
planar sensors for microtiterplates and culture vials
sensor arrays and pattern recognition
Materials for Optical Sensors (polymers, plasticizers, etc.)
polymers with permeation selectivity (hydrophilic vs. hydrophobic)
dye-retaining polymers for sensors
surface-reactive polymers
molecular imprints
polyanilines & polypyrroles
fluorescent microbeads & nanobeads
Optical Biosensors
using immobilized enzymes
using immobilized cells
for substrates of oxidases (glucose etc.)
for substrates of hydrolases (urea)
for enzyme activity and enzyme inhibitors
Fluorescently Labeled Beads
hydrophobic beads
hydrophobic beads
nanobeads (20 nm)
beads with reactive surfaces
Fluorescence Imaging Using Planar Sensors
intensity-based
lifetime-based
DLR-based
of microtiterplates
of oxygen and pH
of hydrogen peroxide and glucose
of temperature
Surface and Interface Chemistry
chemical modification of surfaces (glass, metals, organic polymers, beads)
immobilization of dyes and biomolecules
surface characterization (fluorescence, AFM, SFM, fluorescence microscopy)
click chemistry reagents for use in surface chemistry
Assays Based on Lanthanoide Probes
for H2O2
for peroxidase, catalase, oxidases
substrate assays (glucose, phenol)
EuTc-based ELISA (POx, catalase, GOx)
gated assays (µs domain)
In Optical Sensor Technology
first optical chemical sensor ever commercialized (1984)
first 2-parameter sensor (halothane & oxygen; 1985)
first use of ion carriers in optical sensing (1986)
first use of potential-sensitive dyes in optical sensing (1986)
first LED-based sensor (1986)
first use of ruthenium complexes as oxygen probes (1986)
first optical sensor for detection of enzyme activity (1986)
first lifetime-based optical sensor (oxygen; 1988)
first multi-color sensor (for CO2/O2; 1988)
first microbial optical sensor (1992)
capillary sensors (1995)
first pH and potassium decay time-based sensors in µs time regime (1996)
first disposable cuvettes with integrated sensor layers (1996)
microplates with integrated optical chemical sensors (1996; oxygen, pH)
dual lifetime referenced (DLR) sensors (2000)
frst chloride sensor for blood analysis (2004)
In Fluorescence Spectroscopy
first acquisition of 2D-spectra of serum and urine, and interpretation of peaks (1983-1986)
discovery of dual luminophore referencing (DLR; 1997) as an alternative to lifetime sensing
FRET in nanobeads (2003)
modified dual DLR sensing (td, ft) (2006)
In Imaging
DLR imaging (2001)
detection of skin tumor via oxygen imaging
monitoring cell growth (chondrocytes) via pH imaging and oxygen imaging
first methods for imaging hydrogen peroxide, glucose, and glucose oxidase (2003 – 2005)
simultaneous imaging of oxygen and temperature (2006)
In Designing Fluorescent Probes
first chloride-sensitive fluorescent probes (1982-1984)
first diode-laser excitable and specific probe for albumin (1992)
first fluorescent ruthenium probe for saccharides (1998)
EuTc as a Eu3+-based fluorescent probe for hydrogen peroxide (2002)
optically encoded nanobeads for bioassays (2003)
first fluorescent probes (Eu3+-based) for phosphate and phosphate esters (2004)
terbium-based ultrasensitive DNA probe (2005)
http://www-analytik.chemie.uni-regensburg.de/Wolfbeis/
[ 本帖最后由 sally208 于 2008-6-24 21:22 编辑 ]